{"id":3474,"date":"2025-10-31T11:12:59","date_gmt":"2025-10-31T10:12:59","guid":{"rendered":"https:\/\/neuraldesigner.com\/learning\/colon-cancer-liver-metastasis-simulator\/"},"modified":"2026-02-11T11:01:23","modified_gmt":"2026-02-11T10:01:23","slug":"colon-cancer-liver-metastasis-simulator","status":"publish","type":"learning","link":"https:\/\/www.neuraldesigner.com\/learning\/examples\/colon-cancer-liver-metastasis-simulator\/","title":{"rendered":"Colon cancer metastasis risk prediction simulator"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3474\" class=\"elementor elementor-3474\" data-elementor-post-type=\"learning\">\n\t\t\t\t<div class=\"elementor-element elementor-element-77c86e5 e-grid e-con-boxed e-con e-parent\" data-id=\"77c86e5\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0663405 elementor-widget elementor-widget-text-editor\" data-id=\"0663405\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"160\" data-end=\"347\">Early detection and prognosis of\u00a0<a href=\"https:\/\/www.neuraldesigner.com\/wp-content\/uploads\/2023\/10\/liver_metastasis_colon_cancer.csv\">colon cancer metastasis<\/a>\u00a0are critical for patient survival, yet remain challenging due to the interaction of clinical, pathological, and genetic factors. We present a machine learning simulator for colon cancer liver metastasis risk prediction that estimates 3-year mortality by integrating genomic, mutational, and clinical data, providing individualized risk scores to support oncologists and researchers.<\/p><p data-start=\"620\" data-end=\"759\">This tool bridges clinical and genomic data with practical applications, helping improve\u00a0<a href=\"https:\/\/my.clevelandclinic.org\/health\/articles\/prognosis\">prognosis<\/a>\u00a0assessment in metastatic colon cancer.<\/p><p data-start=\"766\" data-end=\"840\" data-is-last-node=\"\">Healthcare professionals can test it with\u00a0<a href=\"http:\/\/www.neuraldesigner.com\/downloads\">Neural Designer<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a63f85 e-con-full e-flex e-con e-child\" data-id=\"0a63f85\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bd7703e elementor-align-center elementor-widget__width-initial boton_descarga elementor-widget elementor-widget-button\" data-id=\"bd7703e\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.neuraldesigner.com\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-download\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M216 0h80c13.3 0 24 10.7 24 24v168h87.7c17.8 0 26.7 21.5 14.1 34.1L269.7 378.3c-7.5 7.5-19.8 7.5-27.3 0L90.1 226.1c-12.6-12.6-3.7-34.1 14.1-34.1H192V24c0-13.3 10.7-24 24-24zm296 376v112c0 13.3-10.7 24-24 24H24c-13.3 0-24-10.7-24-24V376c0-13.3 10.7-24 24-24h146.7l49 49c20.1 20.1 52.5 20.1 72.6 0l49-49H488c13.3 0 24 10.7 24 24zm-124 88c0-11-9-20-20-20s-20 9-20 20 9 20 20 20 20-9 20-20zm64 0c0-11-9-20-20-20s-20 9-20 20 9 20 20 20 20-9 20-20z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download Free Trial<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aba4e72 e-con-full e-flex e-con e-child\" data-id=\"aba4e72\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-385534e elementor-widget elementor-widget-text-editor\" data-id=\"385534e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<h3 style=\"text-align: center;\">Inputs:<\/h3><p><!--<\/p>\n<div style=\"overflow-x: auto;\">\n<p><span data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\" class=\"mce_SELRES_start\"><\/span><\/p>\n<p>--><\/p><div style=\"display: block; text-align: center;\" align=\"center\"><form style=\"display: inline-block; margin-left: auto; margin-right: auto; text-align: left;\"><table class=\"form\" border=\"1px\" width=\"200px\"><tbody><tr style=\"height: 4em;\"><td>Type of Adenocarcinoma:<\/td><td style=\"text-align: center;\"><select id=\"cancertype\" class=\"minimalwhite\" name=\"cancertype\"><option value=\"0\">Colon<\/option><option value=\"1\">Rectal<\/option><option value=\"2\">Colorectal<\/option><\/select><\/td><\/tr><tr style=\"height: 3.5em;\"><td>Metastasis primary site count:<\/td><td style=\"text-align: center;\"><input id=\"msc\" max=\"15\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"msc_text\" class=\"tabla\" max=\"15\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 4em;\"><td>Microsatellite instability score:<\/td><td style=\"text-align: center;\"><input id=\"msis\" max=\"55\" min=\"0\" step=\"0.01\" type=\"range\" value=\"3.57\" \/><br \/><input id=\"msis_text\" class=\"tabla\" max=\"55\" min=\"0\" step=\"0.01\" type=\"number\" value=\"3.57\" \/><\/td><\/tr><tr style=\"height: 4.5em;\"><td>Microsatellite instability type:<\/td><td style=\"text-align: center;\"><select id=\"msitype\" class=\"minimalwhite\" name=\"msitype\"><option value=\"0\">Stable<\/option><option value=\"1\">Indeterminate<\/option><option value=\"2\">Instable<\/option><option value=\"3\">Do not report<\/option><\/select><\/td><\/tr><tr style=\"height: 3.5em;\"><td>Mutation count:<\/td><td style=\"text-align: center;\"><input id=\"mut\" max=\"472\" min=\"1\" step=\"1\" type=\"range\" value=\"13\" \/><br \/><input id=\"mut_text\" class=\"tabla\" max=\"472\" min=\"1\" step=\"1\" type=\"number\" value=\"13\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>Cancer microsatellite subtype:<\/td><td style=\"text-align: center;\"><select id=\"subtype\" class=\"minimalwhite\" name=\"subtype\"><option value=\"0\">Stable<\/option><option value=\"1\">Hypermutated<\/option><\/select><\/td><\/tr><tr style=\"height: 3.5em;\"><td>Tumour mutational burden:<\/td><td style=\"text-align: center;\"><input id=\"tmb\" max=\"407\" min=\"0.8\" step=\"0.1\" type=\"range\" value=\"12\" \/><br \/><input id=\"tmb_text\" class=\"tabla\" max=\"407\" min=\"0.8\" step=\"0.1\" type=\"number\" value=\"12\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>KIT mutation count:<\/td><td style=\"text-align: center;\"><input id=\"kit\" max=\"3\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"kit_text\" class=\"tabla\" max=\"3\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>CARD11 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"card11\" max=\"5\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"card11_text\" class=\"tabla\" max=\"5\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>RB1 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"rb1\" max=\"3\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"rb1_text\" class=\"tabla\" max=\"3\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>WT1 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"wt1\" max=\"2\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"wt1_text\" class=\"tabla\" max=\"2\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>PLCG2 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"plcg2\" max=\"3\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"plcg2_text\" class=\"tabla\" max=\"3\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>DNMT1 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"dnmt1\" max=\"6\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"dnmt1_text\" class=\"tabla\" max=\"6\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>BRD4 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"brd4\" max=\"3\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"brd4_text\" class=\"tabla\" max=\"3\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>PIK3R1 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"pik3r1\" max=\"3\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"pik3r1_text\" class=\"tabla\" max=\"3\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>IRS2 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"irs2\" max=\"4\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"irs2_text\" class=\"tabla\" max=\"4\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>SESN1 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"sesn1\" max=\"2\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"sesn1_text\" class=\"tabla\" max=\"2\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td>NPM1 mutation count:<\/td><td style=\"text-align: center;\"><input id=\"npm1\" max=\"1\" min=\"0\" step=\"1\" type=\"range\" value=\"0\" \/><br \/><input id=\"npm1_text\" class=\"tabla\" max=\"1\" min=\"0\" step=\"1\" type=\"number\" value=\"0\" \/><\/td><\/tr><tr style=\"height: 3.5em;\"><td><b>Liver metastasis risk:<\/b><\/td><td style=\"text-align: right;\"><output id=\"liver\" name=\"liver\"><b>6.33%<\/b><\/output><\/td><\/tr><\/tbody><\/table><\/form><\/div><p><script>\n\t\t\tfunction neuralNetwork() {\n\t\t\t\tvar cancer_type = document.getElementById(\"cancertype\").value;\n\t\t\t\tvar colon;\n\t\t\t\tvar rectal;\n\t\t\t\tvar colorectal;\n\t\t\t\tif (cancer_type == 0) {\n\t\t\t\t\tcolon = 1;\n\t\t\t\t\trectal = 0;\n\t\t\t\t\tcolorectal = 0;\n\t\t\t\t} else if (cancer_type == 1) {\n\t\t\t\t\tcolon = 0;\n\t\t\t\t\trectal = 1;\n\t\t\t\t\tcolorectal = 0;\n\t\t\t\t} else if (cancer_type == 2) {\n\t\t\t\t\tcolon = 0;\n\t\t\t\t\trectal = 0;\n\t\t\t\t\tcolorectal = 1;\n\t\t\t\t}\n\t\t\t\tvar met_site_count = document.getElementById(\"msc\").value;\n\t\t\t\tvar msi_score = document.getElementById(\"msis\").value;\n\n\t\t\t\tvar msi_type = document.getElementById(\"msitype\").value;\n\t\t\t\tvar stable;\n\t\t\t\tvar indeterminate;\n\t\t\t\tvar instable;\n\t\t\t\tvar donotreport;\n\t\t\t\tif (msi_type == 0) {\n\t\t\t\t\tstable = 1;\n\t\t\t\t\tindeterminate = 0;\n\t\t\t\t\tinstable = 0;\n\t\t\t\t\tdonotreport = 0;\n\t\t\t\t} else if (msi_type == 1) {\n\t\t\t\t\tstable = 0;\n\t\t\t\t\tindeterminate = 1;\n\t\t\t\t\tinstable = 0;\n\t\t\t\t\tdonotreport = 0;\n\t\t\t\t} else if (msi_type == 2) {\n\t\t\t\t\tstable = 0;\n\t\t\t\t\tindeterminate = 0;\n\t\t\t\t\tinstable = 1;\n\t\t\t\t\tdonotreport = 0;\n\t\t\t\t} else if (msi_type == 3) {\n\t\t\t\t\tstable = 0;\n\t\t\t\t\tindeterminate = 0;\n\t\t\t\t\tinstable = 0;\n\t\t\t\t\tdonotreport = 1;\n\t\t\t\t}\n\n\t\t\t\tvar mutation_count = +document.getElementById(\"mut\").value;\n\t\t\t\tvar subtype = +document.getElementById(\"subtype\").value;\n\t\t\t\tvar tmb_nonsynonymous = +document.getElementById(\"tmb\").value;\n\t\t\t\tvar KIT = +document.getElementById(\"kit\").value;\n\t\t\t\tvar CARD11 = +document.getElementById(\"card11\").value;\n\t\t\t\tvar RB1 = +document.getElementById(\"rb1\").value;\n\t\t\t\tvar WT1 = +document.getElementById(\"wt1\").value;\n\t\t\t\tvar PLCG2 = +document.getElementById(\"plcg2\").value;\n\t\t\t\tvar DNMT1 = +document.getElementById(\"dnmt1\").value;\n\t\t\t\tvar BRD4 = +document.getElementById(\"brd4\").value;\n\t\t\t\tvar PIK3R1 = +document.getElementById(\"pik3r1\").value;\n\t\t\t\tvar IRS2 = +document.getElementById(\"irs2\").value;\n\t\t\t\tvar SESN1 = +document.getElementById(\"sesn1\").value;\n\t\t\t\tvar NPM1 = +document.getElementById(\"npm1\").value;\n\n\t\t\t\tvar scaled_colon = colon * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\t\t\t\tvar scaled_rectal = rectal * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\t\t\t\tvar scaled_colorectal = colorectal * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\t\t\t\tvar scaled_met_site_count = (met_site_count - 3.15437007) \/ 2.403779984;\n\t\t\t\tvar scaled_msi_score = (msi_score - 3.579030037) \/ 9.864089966;\n\t\t\t\tvar scaled_stable = stable * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\t\t\t\tvar scaled_indeterminate = indeterminate * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\t\t\t\tvar scaled_instable = instable * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\t\t\t\tvar scaled_donotreport = donotreport * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\t\t\t\tvar scaled_mutation_count = (mutation_count - 13.76679993) \/ 27.63050079;\n\t\t\t\tvar scaled_subtype = subtype * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\t\t\t\tvar scaled_tmb_nonsynonymous = (tmb_nonsynonymous - 12.34119987) \/ 24.77930069;\n\t\t\t\tvar scaled_KIT = (KIT - 0.02431439981) \/ 0.1713950038;\n\t\t\t\tvar scaled_CARD11 = (CARD11 - 0.0667231977) \/ 0.2999680042;\n\t\t\t\tvar scaled_RB1 = (RB1 - 0.02685889974) \/ 0.1964139938;\n\t\t\t\tvar scaled_WT1 = (WT1 - 0.01809439994) \/ 0.1435080022;\n\t\t\t\tvar scaled_PLCG2 = (PLCG2 - 0.04156060144) \/ 0.2185139954;\n\t\t\t\tvar scaled_DNMT1 = (DNMT1 - 0.03901610151) \/ 0.2357760072;\n\t\t\t\tvar scaled_BRD4 = (BRD4 - 0.03647160158) \/ 0.2033720016;\n\t\t\t\tvar scaled_PIK3R1 = (PIK3R1 - 0.05597959831) \/ 0.268456012;\n\t\t\t\tvar scaled_IRS2 = (IRS2 - 0.04014699906) \/ 0.2343810052;\n\t\t\t\tvar scaled_SESN1 = (SESN1 - 0.006219959818) \/ 0.08213800192;\n\t\t\t\tvar scaled_NPM1 = NPM1 * (1 + 1) \/ (1 - (0)) - 0 * (1 + 1) \/ (1 - 0) - 1;\n\n\t\t\t\tvar probabilistic_layer_combinations_0 = 0.0150952 + 0.157874 * scaled_colon - 0.154215 * scaled_rectal - 0.0195006 * scaled_colorectal + 1.68684 * scaled_met_site_count + 0.158263 * scaled_msi_score - 0.066526 * scaled_stable + 0.547837 * scaled_indeterminate - 0.471286 * scaled_instable - 0.0375401 * scaled_donotreport - 0.181048 * scaled_mutation_count + 0.611953 * scaled_subtype + 0.0808695 * scaled_tmb_nonsynonymous - 0.0273534 * scaled_KIT + 0.0444354 * scaled_CARD11 + 0.0211164 * scaled_RB1 + 0.0739666 * scaled_WT1 + 0.0429152 * scaled_PLCG2 + 0.00816219 * scaled_DNMT1 - 0.138295 * scaled_BRD4 + 0.0240884 * scaled_PIK3R1 + 0.0625585 * scaled_IRS2 + 0.0364737 * scaled_SESN1 + 0.0926002 * scaled_NPM1\n\n\t\t\t\tvar distant_mets_liver = 1.0 \/ (1.0 + Math.exp(-probabilistic_layer_combinations_0));\n\n\t\t\t\tdocument.getElementById(\"liver\").innerHTML = (distant_mets_liver * 100).toFixed(2) + \"%\";\n\t\t\t\tdocument.getElementById(\"final\").innerHTML = (distant_mets_liver * 100).toFixed(2) + \"%\";\n\t\t\t\tdocument.getElementById(\"liver\").style.fontWeight = 'bold';\n\t\t\t}\n\n\t\t\tfunction updateTextInput1(val, id) {\n\t\t\t\tdocument.getElementById(id).value = val;\n\t\t\t}\n\t\t<\/script><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0533d14 e-con-full e-flex e-con e-child\" data-id=\"0533d14\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6978779 elementor-widget elementor-widget-heading\" data-id=\"6978779\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Related posts<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"author":13,"featured_media":12745,"template":"","categories":[29],"tags":[38],"class_list":["post-3474","learning","type-learning","status-publish","has-post-thumbnail","hentry","category-examples","tag-healthcare"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Colon cancer metastasis risk prediction simulator<\/title>\n<meta name=\"description\" content=\"Machine learning simulator for colon cancer metastasis risk prediction, estimating 3-year mortality from genomic, mutational, and clinical data.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.neuraldesigner.com\/learning\/examples\/colon-cancer-liver-metastasis-simulator\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Colon cancer liver metastasis machine learning example\" \/>\n<meta property=\"og:description\" content=\"This example aims to assess the probability to suffer liver metastasis in colorectal patients from mutational data.\" \/>\n<meta property=\"og:url\" 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